Tag : Regiochemistry

A Study of Regiochemistry and Stereochemistry in the Hydroboration-Oxidation of (1R)-(+)--Pinene

By: Ryan DeAngelis, Andrew Mound Introduction The purpose of this experiment is to synthesize an alcohol using hydroboration-oxidation and determine the regiochemistry and stereochemistry of the product via 1H-NMR, 13C-NMR, and Infrared spectroscopy.1 Hydroboration-Oxidation is a two-step process used to convert an alkene to an alcohol. The first step, hydroboration, is the addition of borane (BH3) to the alkene. It proceeds as a concerted mechanism with the electron pair in the pi bond attacking the electrophilic boron, and one of […]